This is what I have to do to get them running correctly.
- Go into CCC then click on the "Desktop Management Tab."
- Click on "Creating and Arranging Desktops"
- Now under "Please select a display" disable all displays except 1 by using the drop down menu when you right click the down arrow on the monitors.
- Now under that same place, right click the disabled monitors and duplicate them all. Every monitor icon should not have 1 on the top left hand corner.
- Next go to the "AMD Eyefinity (TM) Multi-Display" Tab and Click on the "Create Eyefinity Display Group" and make sure not to disable any displays w hen it ask.
- Follow the on screen instructions and arrange the monitors at the end of the group and now you should be in 5x1 greatness.
I hope this helps.
EDIT: Tl,Dr: Make sure you duplicate all the displays you want to eyefinity with before you try to make an eyefinity group. It make a pseudo group in chich makes the process easier.