With bezel compensation setup you just need to set the in-game resolution to the bezel compensated resolution to use it.
You do not even need to have your current desktop set to your bezel compensated resolution, and vice versa you can have your desktop set to the bezel comp res and then have the game set to your standard eyefinity res and it wont work.
The most common and probably issue is that your in game resolution is not set to the correct one and instead your standard eyefinity resolution.
My first google search pulled up a thread like this: http://realenvironmentxtreme.com/forum
Same issue, same solution that I just mentioned.
Let us know if it works for you.
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