I have exactly the same issue.
Posted it @ AMD a while ago (
https://community.amd.com/thread/183443). No comments/solutions, unfortunately.
Most of the time I play racing games. But the general idea/problem is clear.
I also tried many, many offered solutions (mouse trails off (if on), disabled all Windows eye candy, etc).
Still no solution found.
Funny thing is that I have the same setup: Windows 7, 64 bit, PLP (1 Dell 30" and 2 Dell 20").
I also have to re-enable eyefinity every day. Do you encounter the same problem with that, Illogique?