Triple 1280x1024 is probably best for you, although the TripleHEad2Go is not desinged to be used with a widescreen monitor in the middle and 5:4 monitors on the sides.
With the latest Matrox update you can run dualhead, but the available resolutions are 2560x1024 (double 1280x1024) and 3360x1050 (double 1680x1050). The unit does not allow for assymetric dualscreen use. However, you could run your center screen in single-screen mode at 1680x1050 (just set this dekstop resolution and the TripleHead2Go will put it on the center monitor and put the other two in standby, and then run other monitors off of other video card outputs at their own resolutions, if you have monitors with dual inputs.
You have a pretty hefty system, so you shouldn't see too much of a framrate hit. It will be most apparant in game that are already GPU-limited on your current system.
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