Your issue sounds a little suspect to me. I'm running TOR on the 295 GTX with a Matrox TH2G (also at 5040x1050) but haven't had any issues beyond turning AA off and everything else up at max. Turning shadows to low was an additional change I made later for a little more FPS gain, but... it should run fine. The only difference I really see is that you're running SLI and my CPU is a bit more beefy than your own (3.3 GHz).
Make sure your drivers are up to date, both on your Matrox firmware, PowerDesk, and nVidia drivers- see if that helps at all. You may be surprised.
Also, are you running it windowed, windowed fullscreen, or plain fullscreen?
_________________ nVidia 2D Surround
3x 1920x1080 Dell UltraSharp U2312HM
EVGA GeForce 680 @ 5760x1080
Core i5-2500K 3.3GHz (3.7 Turbo)
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