Native widescreen support - except for 1360x768.
For some reason, this resolution is not available off the in-game list. You'll have to edit the registry:
HKEY_CURRENT_USER\Software\Activision\Singularity
UserSelectedResolution 1
ResX 1360 (DECIMAL value)
ResY 768 (DECIMAL value)
There is no known way to increase the pretty narrow FOV at this time. Key bindings are apparently saved in binary format in Documents\Singularity\RvGame\SaveData\Player0.ue3profile (here's my file if any hex-pert wants to have a look - http://www.wsgfmedia.com/scavvenjahh/singularity/Player0.ue3profile).
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Correct scaling in widescreen. The HUD stretches in multi-mon.
The various iron sights and scope sights are ok, except for the rocket launcher scope and gas mask: in both cases the overlay does not scale correctly and is Vert- instead.
(On a sidenote, the sniper scope's compass is only a cosmetic gizmo: North in 4:3 becomes South in 16:9...)
The MP game is a bit different (slow texture streaming like in the unpatched solo game, 30-fps cap) but support is the same, including the 1360x768 issue. In Soldiers vs. Creatures mode, members of Team Sickle (the bad guys) play from a third-person perspective.