Call of Juarez: The Cartel revolves around a undercover team that has been put together in order to investigate a bombing of an LAPD office. The events pick up in the meeting room where the team is put together, consisting of Ben McCall, an LAPD detective who’s as close to the Western ideals as the game can get, an FBI agent Kim Evans, and Eddie Guerra from DEA. This undercover team is tasked to work in secrecy and carry out their investigation of the bombing, with possible involvement of the local gangsters as well as the Mendoza cartel from Mexico.